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Updated: Aug 18, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
6,7-Di-chloro-2,3-bis(pyridin-2-yl)quinox-aline
Guy Crundwell1, Neil M Glagovich1, Melissa E King1
1Department of Chemistry & Biochemistry, Central Connecticut State University, New Britain, CT 06053, USA.
Abstract:
The title compound, C18H10Cl2N4, synthesized by the condensation reaction between 4,5-di-chloro-benzene-1,2-di-amine and 1,2-di(pyridin-2-yl)ethane-1,2-dione in boiling acetic acid, has a nearly planar quinoxaline moiety [maximum deviation = 0.070 (1) Å] whose mean plane makes dihedral angles of 40.51 (2) and 39.29 (3)° with the pyridine rings. Within the unit cell, there are no classical hydrogen bonds. Molecules in the structure pack with π-π stacking contacts between the quinoxaline units and nearby pyridine rings with an intercentroid distance of 3.7676 (9) Å.
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