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A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Sesquiterpenoids with Anti-MDR Staphylococcus aureus activities from Ferula ferulioides
Tao Liu1, Shuangying Wang, Lili Xu
1School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Pudong, Shanghai 201203, P. R. China (phone: +86-21-51980109).
Abstract:
Seven new sesquiterpenoids together with 21 known sesquiterpenoid derivatives were isolated from the medicinal plant Ferula ferulioides (Steud.) Korovin. Their structures were elucidated by comprehensive spectroscopic analyses and chemical transformations. The isolated compounds were evaluated for their antibacterial activities against a panel of bacteria including multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA), displaying minimum inhibitory concentration (MIC) values in the range of 0.5-128 mg/l.
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