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Influence of circadian blood pressure profile on endothelial function in patients with and without arterial

A Rekhviashvili1, T Giorgobiani1, A Minashvili1

  • 1Archangel St. Michael Multiprofile Clinical Hospital; Shotadze Tbilisi Medical Academy, Georgia.

Georgian Medical News
|April 17, 2015
PubMed

Insights

Essential hypertension patients with a non-dipper blood pressure (BP) rhythm show impaired endothelial function. This suggests non-dipper BP profiles indicate higher cardiovascular risk, requiring closer monitoring.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Vascular Biology

Background:

  • The link between circadian blood pressure (BP) patterns and endothelial function in essential hypertension is poorly understood.
  • Essential hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases.

Purpose of the Study:

  • To investigate the relationship between circadian BP profiles and endothelial function in hypertensive patients.
  • To determine if non-dipper BP patterns are associated with worse endothelial function compared to dipper patterns.

Main Methods:

  • Utilized 24-hour ambulatory BP monitoring (ABPM) and high-resolution ultrasound for vascular doppler-echography.
  • Assessed endothelial function via flow-mediated dilation (FMD%) in 57 untreated hypertensive patients and 17 controls.
  • Conducted anthropometrical measurements, physical examinations, and medical history reviews.

Main Results:

  • Dipper BP profiles were more common in normotensive individuals.
  • Dipper patients exhibited significantly higher flow-mediated dilation (FMD%), independent of hypertension status.
  • FMD% strongly correlated negatively with 24-hour systolic BP, diastolic BP, and pulse pressure.

Conclusions:

  • Confirmed impaired endothelium-dependent vasodilation in patients with essential hypertension.
  • Demonstrated that a non-dipper circadian BP rhythm is linked to significantly impaired endothelial function.
  • Identified non-dipper circadian BP profiles as a potential marker for high cardiovascular risk, warranting closer patient supervision.

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