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The woolly monkey (Lagothrix lagothricha): a possible model for human hypertension research
Schweizer Archiv Fur Tierheilkunde
|January 1, 1989
Summary
Essential hypertension in woolly monkeys shares pathological similarities with human hypertension. This multifactorial disease may be linked to lifestyle and stress, suggesting a high vulnerability in this primate genus.
Area of Science:
- Veterinary Pathology
- Primate Medicine
- Comparative Pathology
Background:
- Essential hypertension is a significant health concern in humans.
- Understanding hypertension in non-human primates can offer comparative insights into disease mechanisms.
- Woolly monkeys (genus Lagothrix) are susceptible to various health issues.
Purpose of the Study:
- To describe the anatomical-pathological findings in woolly monkeys with suspected essential hypertension.
- To compare these findings with human hypertension.
- To investigate potential contributing factors and the vulnerability of woolly monkeys to hypertension.
Main Methods:
- Post-mortem examination of 15 woolly monkeys.
- Histopathological analysis of kidney tissues.
- Assessment of arterio- and arteriolosclerosis, and necrotizing endarteritis.
Main Results:
- Kidney findings in woolly monkeys included arterio- and arteriolosclerosis and onion peel-like proliferation.
- Necrotizing endarteritis was observed in some cases.
- Pathological features were comparable to those seen in human essential hypertension.
Conclusions:
- Essential hypertension in woolly monkeys presents with pathological characteristics similar to humans.
- Multifactorial causes, including obesity, inactivity, unnatural diet, and stress, are postulated.
- Woolly monkeys may possess a high vulnerability to developing essential hypertension.
