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Forward Genetic Approaches in Chlamydia trachomatis

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

Chlamydia (uncomplicated, genital).

Megan Crofts¹, Paddy Horner

¹Bristol Sexual Health Service, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

BMJ Clinical Evidence

|April 17, 2015

Summary

This summary is machine-generated.

This systematic review evaluates antibiotic treatments for genital chlamydia, a common bacterial sexually transmitted infection. It assesses the effectiveness and safety of various antibiotic regimens for men, non-pregnant women, and pregnant women.

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Area of Science:

Medical Research
Infectious Diseases
Public Health

Background:

Genital chlamydia is the most frequently reported bacterial sexually transmitted infection in developed nations.
Young adults, particularly those under 25, represent the demographic most affected by genital chlamydia infections.

Purpose of the Study:

To systematically review the effects of antibiotic treatments for uncomplicated genital chlamydial infections in men and non-pregnant women.
To evaluate the effects of antibiotic treatments for uncomplicated genital chlamydial infections in pregnant women.

Main Methods:

A systematic review was conducted, searching major databases like Medline and Embase up to February 2014.
Included studies involved antibiotic interventions for genital chlamydia in men, non-pregnant women, and pregnant women.
Harms alerts from regulatory agencies (FDA, MHRA) were incorporated into the review.

Main Results:

Twenty-six studies met the inclusion criteria for the systematic review.
A GRADE evaluation was performed to assess the quality of evidence for the interventions studied.
Data on the effectiveness and safety of various antibiotic treatments were compiled.

Conclusions:

The review presents information on the effectiveness and safety of single-dose and multiple-dose antibiotic regimens for men and non-pregnant women.
For pregnant women, the effectiveness and safety of single-dose antibiotics, erythromycin, amoxicillin, and clindamycin (multiple-dose regimens) were assessed.