Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spatial patterns from oscillating microtubules.

E Mandelkow1, E M Mandelkow, H Hotani

  • 1Max-Planck-Unit for Structural Molecular Biology, Hamburg, West Germany.

Science (New York, N.Y.)
|December 8, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Statistics Measurement of the Cosmic-Ray Electron Spectrum with H.E.S.S.

Physical review letters·2024
Same author

The accelerated weight histogram method for alchemical free energy calculations.

The Journal of chemical physics·2021
Same author

Effects of sodium bicarbonate infusion on mortality in medical-surgical ICU patients with metabolic acidosis-A single-center propensity score matched analysis.

Medicina intensiva·2021
Same author

Regularizing the fast multipole method for use in molecular simulation.

The Journal of chemical physics·2019
Same author

Chaotic properties of spin lattices near second-order phase transitions.

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same author

[Ultrasound-guided infraclavicular venipuncture at the junction of the axillary and subclavian veins].

Der Anaesthesist·2014
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
See all related articles

Cytoskeletal proteins like tubulin can self-organize into dynamic patterns, such as traveling waves and networks, demonstrating biomolecular pattern formation without cellular structures.

Area of Science:

  • Cell Biology
  • Biophysics
  • Biochemistry

Background:

  • Microtubules are essential cytoskeletal fibers influencing cell shape and motility.
  • Microtubules exhibit dynamic assembly states and temporal oscillations.

Purpose of the Study:

  • To investigate the self-organization capabilities of microtubule components.
  • To explore pattern formation in biomolecular systems in vitro.

Main Methods:

  • Utilizing solutions of tubulin and guanosine triphosphate (GTP).
  • Observing the formation of dissipative structures.

Main Results:

  • Tubulin and GTP solutions spontaneously formed dynamic spatial structures.
  • Observed structures included traveling waves of assembly/disassembly and polygonal networks.

Related Experiment Videos

  • Pattern formation occurred independently of cellular organizing centers.

    • Conclusions:

    • Cytoskeletal proteins can autonomously generate complex spatial patterns.
    • The microtubule system serves as a simplified model for in vitro biomolecular pattern formation studies.