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Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
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Of men and meals.

J Beyer-Westendorf1, G Siegert2

  • 1Center for Vascular Diseases and Medical Clinic III, University Hospital 'Carl Gustav Carus', Technische Univesität, Dresden, Germany.

Journal of Thrombosis and Haemostasis : JTH
|April 17, 2015
PubMed
Summary
This summary is machine-generated.

Rivaroxaban absorption is reduced when fasting, increasing VTE risk. Clinical evidence suggests taking rivaroxaban with meals is crucial for effective treatment and preventing recurrent events.

Keywords:
anticoagulant drugsdeep vein thrombosisfastingrecurrencerivaroxabanvenous thromboembolism

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Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Thrombosis Research

Background:

  • Rivaroxaban is a widely used anticoagulant for venous thromboembolism (VTE).
  • Current recommendations advise taking rivaroxaban with meals, based on preclinical data.
  • Clinical evidence supporting this recommendation in VTE patients is lacking.

Observation:

  • A compliant young patient experienced recurrent pulmonary embolism while on rivaroxaban therapy.
  • Pharmacokinetic studies indicated rivaroxaban malabsorption due to irregular meal intake during shift work.
  • This malabsorption was identified as the primary cause of recurrent VTE.

Findings:

  • Irregular meal intake significantly impairs rivaroxaban absorption in VTE patients.
  • Consistent intake with meals dramatically increased peak plasma concentrations (+176%).
  • Case demonstrates clinical relevance of food intake for rivaroxaban efficacy.

Implications:

  • The clinical significance of taking rivaroxaban with food may be underestimated.
  • Patient education on consistent meal intake is vital for optimal rivaroxaban therapy.
  • Further clinical studies are warranted to confirm the impact of food on rivaroxaban in VTE management.