Related Experiment Video
Updated: Apr 14, 2026
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Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
Published on: December 16, 2022
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Of men and meals
J Beyer-Westendorf1, G Siegert2
1Center for Vascular Diseases and Medical Clinic III, University Hospital 'Carl Gustav Carus', Technische Univesität, Dresden, Germany.
Journal of Thrombosis and Haemostasis : JTH
|April 17, 2015
Summary
Rivaroxaban absorption is reduced when fasting, increasing VTE risk. Clinical evidence suggests taking rivaroxaban with meals is crucial for effective treatment and preventing recurrent events.
Area of Science:
- Pharmacology
- Clinical Medicine
- Thrombosis Research
Background:
- Rivaroxaban is a widely used anticoagulant for venous thromboembolism (VTE).
- Current recommendations advise taking rivaroxaban with meals, based on preclinical data.
- Clinical evidence supporting this recommendation in VTE patients is lacking.
Observation:
- A compliant young patient experienced recurrent pulmonary embolism while on rivaroxaban therapy.
- Pharmacokinetic studies indicated rivaroxaban malabsorption due to irregular meal intake during shift work.
- This malabsorption was identified as the primary cause of recurrent VTE.
Findings:
- Irregular meal intake significantly impairs rivaroxaban absorption in VTE patients.
- Consistent intake with meals dramatically increased peak plasma concentrations (+176%).
- Case demonstrates clinical relevance of food intake for rivaroxaban efficacy.
Implications:
- The clinical significance of taking rivaroxaban with food may be underestimated.
- Patient education on consistent meal intake is vital for optimal rivaroxaban therapy.
- Further clinical studies are warranted to confirm the impact of food on rivaroxaban in VTE management.
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