Related Experiment Video
Updated: Apr 14, 2026
RNAi Trigger Delivery into Anopheles gambiae Pupae
Published on: March 8, 2016
The sterilizing effect of pyriproxyfen on the malaria vector Anopheles gambiae: physiological impact on ovaries
Bayili Koama1, Moussa Namountougou2,3, Roger Sanou4
1Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Ouagadougou, Burkina Faso. kwamajacques@yahoo.fr.
Abstract:
Adult females An. gambiae were exposed in 3 min cone test to treated nets with PPF before or after they were blood fed. The effects of PPF on ovaries development, females oviposition and eggs hatching were assessed. Both unfed and fed mosquitoes exposed to PPF exhibited nearly complete inhibition of fecundity (70-100%) and fertility (90-100%). After females have been exposed once to PPF, the sterilizing effect on their fecundity was observed over 3 consecutive blood meals suggesting that PPF might have an irreversible sterilizing effect. Observation of the ovaries of exposed females to PPF under microscope revealed that the ovaries failed to develop even after several blood meals. The combination of PPF to pyrethroids on bednets could provide better malaria control tool and prevent the further development and spread of pyrethroid resistance in malaria vectors.
