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[Chronic constipation and its treatment].

V G Smagin, L M Ivanova, G M Iukina

    Terapevticheskii Arkhiv
    |January 1, 1989
    PubMed
    Summary
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    Chronic constipation patients often have functional intestinal changes and dysbacteriosis. Multimodality treatment effectively improved symptoms for most, reducing laxative dependence.

    Area of Science:

    • Gastroenterology
    • Microbiome research

    Context:

    • Chronic constipation affects a significant patient population.
    • Intestinal changes and dysbacteriosis are common in chronic constipation.

    Purpose:

    • To investigate the intestinal changes and prevalence of dysbacteriosis in chronic constipation patients.
    • To evaluate the efficacy of multimodality treatment for chronic constipation.

    Summary:

    • 850 chronic constipation patients were studied.
    • 80% had functional intestinal changes, 5% lost defecation reflex, 15% had inflammation-induced lesions.
    • Dysbacteriosis was present in 80% of patients.
    • Multimodality treatment showed significant positive effects, leading to reduced laxative use in many patients.

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    Impact:

    • Highlights the high prevalence of functional changes and dysbacteriosis in chronic constipation.
    • Demonstrates the effectiveness of multimodality treatment, offering a potential alternative to laxatives.
    • Suggests a link between gut microbiome and chronic constipation, warranting further research.