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Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
Study design, rationale and methods for a population-based study of myopia in schoolchildren: the Myopia
Der-Chong Tsai1,2, Li-Ju Lin3, Nicole Huang4
1School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Background:
To describe the study design, rationale and methodology of the Myopia Investigation Study in Taipei (MIT).
Design:
The MIT was a city-wide, population-based cohort study.
Participants:
Participants were grade 2 students (Fall 2013) of all 153 elementary schools in Taipei City.
Methods:
The baseline data on the risk factors for myopia development was collected by parent-administered questionnaire surveys covering demographics, medical history, parental myopia, time spent on near work and outdoor activities, reading habits and eye care-seeking behaviour. Ocular examinations focused on the measurement of visual acuity (unaided and best-corrected) and refractive status (before and after cycloplegia), which will be carried out for the eligible schoolchildren biannually for 3 years consecutively. Once myopic children are identified, case manager-led telecoaching for health-care instructions and reminders will be delivered to parents or caregivers.
Main Outcome Measures:
To build a comprehensive database for prevalence, incidence and risk factors of early childhood myopia over a 3-year follow-up period.
Results:
Of all 19 374 eight-year-old schoolchildren (10 210 [52.7%] boys) eligible for the MIT, 16 486 (85.1%) responded to the questionnaire, 12 019 (62.0%) were examined during the third quarter of 2013 and 11 590 (59.8%) (6267 [52.9%] boys) completed cycloplegic autorefraction on both eyes and were enrolled for further data analysis. There was no significant difference in terms of demographics between the analysed participants and all grade 2 students in Taipei City.
Conclusions:
Data from the MIT will provide population-based information concerning the prevalence, incidence and risk factors for myopia development among young schoolchildren in a metropolitan area of Taiwan.
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