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Related Experiment Video

Updated: Apr 14, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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Published on: September 16, 2021

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Optimal timing for elective egg freezing.

Tolga B Mesen1, Jennifer E Mersereau1, Jennifer B Kane2

  • 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.

Fertility and Sterility
|April 18, 2015
PubMed
Summary
This summary is machine-generated.

Elective oocyte cryopreservation offers significant benefits for live birth probability, particularly when performed around age 37. While earlier freezing yields higher success rates, age 37 presents the optimal balance of benefit and cost-effectiveness.

Keywords:
Elective oocyte cryopreservationegg freezingfertility preservation

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Area of Science:

  • Reproductive Endocrinology
  • Decision Analysis
  • Health Economics

Background:

  • Elective oocyte cryopreservation (EOC) is an option for women delaying childbearing.
  • Determining the optimal age for EOC is crucial for maximizing success and cost-effectiveness.

Purpose of the Study:

  • To estimate the optimal age for pursuing elective oocyte cryopreservation.
  • To evaluate the success and cost-effectiveness of EOC compared to no intervention.

Main Methods:

  • A decision-tree model was developed to simulate outcomes for women aged 25-40 years.
  • The model assessed the probability of live birth and cost-effectiveness of EOC versus natural conception attempts at 3, 5, or 7 years post-decision.

Main Results:

  • EOC at age 37 yielded the greatest improvement in live birth probability (51.6% vs. 21.9%) and was most cost-effective ($28,759 per additional live birth).
  • The highest live birth probability (>74%) was observed with EOC before age 34, but with minimal benefit over no action between ages 25-30.
  • Including marriage probability in the model reduced the perceived benefit of EOC.

Conclusions:

  • Elective oocyte cryopreservation can significantly benefit specific women, with success rates highest when performed at younger ages.
  • Age 37 represents a key decision point, offering the largest benefit over no action and optimal cost-effectiveness for EOC.