Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

964
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
964
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

861
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
861
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.0K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.0K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

1.2K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.2K
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

59
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
59
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

466
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
466

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Water chemistry controlled enhancement of electrokinetic transport and reactant delivery in low-permeability zones.

Water research·2026
Same author

Toward Decarbonized Metal Mining and Shifting Environmental Impacts: A Quantitative Comparative Assessment.

Environmental science & technology·2026
Same author

Giant Maxillary Antral Mucocele Consequent To Allergic Fungal Sinusitis.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2025
Same author

The crucial balance in surgical margins for head and neck oncology.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2025
Same author

The crucial balance in surgical margins for head and neck oncology.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2025
Same author

Prognostic significance of surgical margins in laryngeal cancer treated by transoral laser microsurgery: a systematic review and meta-analysis.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2025

Related Experiment Video

Updated: Apr 14, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

13.2K

Kawasaki disease: an evolving paradigm.

Antonio Greco1, Armando De Virgilio2, Maria Ida Rizzo2

  • 1Department Organs of Sense, ENT Section, University of Rome "La Sapienza", Viale del Policlinico 155, 00100, Roma, Italy.

Autoimmunity Reviews
|April 18, 2015
PubMed
Summary

Kawasaki disease (KD) is a childhood vasculitis affecting coronary arteries, primarily in young children. Diagnosis relies on clinical signs, with echocardiography assessing coronary artery changes, and treatment involving aspirin and IVIG.

Keywords:
AneurysmChildren vasculitisCoronary arteriesIntravenous immunoglobulinsKawasaki disease

More Related Videos

Fertility Preservation in Patients with Severe Ovarian Dysfunction
12:03

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

5.2K
Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
08:56

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Published on: October 10, 2025

914

Related Experiment Videos

Last Updated: Apr 14, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

13.2K
Fertility Preservation in Patients with Severe Ovarian Dysfunction
12:03

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

5.2K
Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
08:56

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Published on: October 10, 2025

914

Area of Science:

  • Pediatrics
  • Rheumatology
  • Immunology

Background:

  • Kawasaki disease (KD) is a self-limited childhood systemic vasculitis.
  • It predominantly affects children aged 6 months to 4 years, with higher incidence in Asians.
  • The etiology remains unknown, with a hypothesis suggesting an infectious trigger in genetically susceptible individuals.

Purpose of the Study:

  • To summarize the clinical presentation, diagnosis, and management of Kawasaki disease.
  • To highlight the importance of echocardiography in detecting coronary artery abnormalities.
  • To review current and alternative therapeutic strategies for acute KD.

Main Methods:

  • Diagnosis is clinical, based on a constellation of symptoms including prolonged fever, rash, and mucosal changes.
  • Echocardiography is crucial for identifying coronary artery dilatation or aneurysm formation.
  • Treatment involves first-line therapies like aspirin and intravenous immunoglobulin (IVIG).

Main Results:

  • Typical presentation includes high fever, cracked lips, strawberry tongue, and cervical lymphadenopathy.
  • Coronary aneurysms typically develop during the convalescence phase.
  • Aspirin and IVIG are effective first-line treatments for most patients.

Conclusions:

  • KD diagnosis is clinical due to the lack of specific laboratory tests.
  • Prompt diagnosis and treatment are essential to prevent coronary artery complications.
  • Alternative therapies like methylprednisolone and infliximab are considered for refractory cases.