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Updated: Apr 14, 2026

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
Published on: October 20, 2023
Treating aortic stenosis: arresting the snowball effect
Tania A Pawade1, David E Newby
11 British Heart Foundation/University Centre for Cardiovascular Science, Room SU 305, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh. EH16 4SB, Edinburgh, UK.
Abstract:
Aortic stenosis is common and potentially fatal. Recent key insights into the pathophysiology of this disease suggest it is likely to represent a self-perpetuating cycle of injury where tissue calcification is the major driver. Also, the mechanisms governing this appear closely related to calcium homeostasis and bone metabolism. Manipulation of these processes may offer a means by which aortic stenosis progression can be inhibited using drugs currently licensed to treat osteoporosis. Indeed, a prospective randomized controlled trial is currently underway for determining whether denosumab or bisphosphonates can slow aortic stenosis disease. If successful, this would meet a major unmet clinical need.
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