Cancer Kinases and its Novel Inhibitors: Past, Present and Future Challenges

Area of Science:

• Biochemistry
• Oncology
• Pharmacology

Background:

• The human kinome comprises over 500 kinases, integral to cellular signaling pathways.
• Kinase dysregulation is implicated in tumor progression and diverse diseases, including immunological and neurological disorders.
• Targeting kinases has emerged as a key strategy for novel cancer drug development.

Purpose of the Study:

• To provide a comprehensive overview of kinases and their inhibitors in cancer therapy.
• To discuss the origin, discovery, and characterization of kinase inhibitors.
• To elucidate the mode of action of kinase inhibitors across various cancer types.

Main Methods:

• Literature review of scientific databases.
• Analysis of kinase families and their roles in oncogenesis.
• Examination of existing and investigational kinase inhibitors for cancer treatment.

Main Results:

• Kinases regulate critical cellular processes including proliferation and signal transduction.
• Inhibitors targeting specific kinases offer a promising therapeutic avenue for cancer treatment.
• A wide array of kinase inhibitors are under clinical investigation for diverse malignancies.

Conclusions:

• Kinase inhibitors represent a significant advancement in targeted cancer therapy.
• Understanding kinase function and inhibition is vital for developing effective cancer drugs.
• Further research into kinase pathways will likely yield new therapeutic strategies for various cancers.