Related Experiment Video
Updated: Apr 14, 2026
03:57
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
2.5K
Hypoparathyroidism - disease update and emerging treatments
Elizabeth L Monis1, Michael Mannstadt1
1Massachusetts General Hospital, Endocrine Unit, Thier 1051, 50 Blossom St, 02114 Boston, USA.
Annales D'Endocrinologie
|April 18, 2015
Summary
Hypoparathyroidism, a condition of insufficient parathyroid hormone (PTH), causes calcium imbalances. New recombinant human (rh) PTH(1-84) therapy offers an alternative treatment for this chronic endocrine disorder.
Area of Science:
- Endocrinology
- Metabolic Bone Disease
Background:
- Parathyroid hormone (PTH) regulates calcium and bone metabolism.
- Hypoparathyroidism results from insufficient PTH, leading to hypocalcemia and hyperphosphatemia.
- It is often caused by thyroid surgery complications.
Purpose of the Study:
- To introduce recombinant human (rh) PTH(1-84) as a novel therapeutic option.
- To address the limitations of current hypoparathyroidism treatments.
Main Methods:
- Review of current treatment strategies for hypoparathyroidism.
- Discussion of the role and approval of rhPTH(1-84).
Main Results:
- Current treatments (calcium, vitamin D) have limitations, including serum calcium fluctuations and renal risks.
- rhPTH(1-84) provides a new therapeutic avenue for managing hypoparathyroidism.
Conclusions:
- Hypoparathyroidism management is challenging with existing therapies.
- PTH replacement therapy with rhPTH(1-84) is a significant advancement in treating hypoparathyroidism.
Related Concept Videos
00:59The Parathyroid Glands
6.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
6.1K
01:26Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
662
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
662
01:17Hormones and Bone Tissue
4.3K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.3K
01:28Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
773
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
773
01:24Parkinson's Disease: Treatment
1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
01:40Bone Remodeling
41.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.3K