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Single High-Dose Oral Vitamin D3 Therapy (Stoss): A Solution to Vitamin D Deficiency in Children With Inflammatory

Darren Shepherd1, Andrew S Day, Steven T Leach

  • 1*Department of Gastroenterology, Sydney Children's Hospital †School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia ‡Department of Pediatrics, University of Otago (Christchurch), Christchurch, New Zealand §Department of Endocrinology, Sydney Children's Hospital, Sydney, New South Wales, Australia ||Department of Paediatric Gastroenterology, Shaare Zedek Medical Center, Jerusalem, Israel.

Journal of Pediatric Gastroenterology and Nutrition
|April 18, 2015
PubMed

Insights

Stoss therapy effectively raised vitamin D levels in children with inflammatory bowel disease (IBD). This treatment safely improved 25-hydroxyvitamin D (25-OHD) levels for six months without affecting calcium or parathyroid hormone.

Area of Science:

  • Pediatric Gastroenterology
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is prevalent in pediatric inflammatory bowel disease (IBD) patients.
  • Maintaining adequate vitamin D is crucial for bone health and immune function in children with IBD.

Purpose of the Study:

  • To evaluate the safety and efficacy of high-dose vitamin D (stoss) therapy in children with IBD and vitamin D deficiency.
  • To assess vitamin D repletion over a six-month period.

Main Methods:

  • Retrospective chart review of pediatric IBD patients at Sydney Children's Hospital (2006-2010).
  • Inclusion criteria: 25-hydroxyvitamin D (25-OHD) level <50 nmol/L and receipt of stoss therapy.
  • Data collected on 25-OHD, serum calcium, phosphate, and parathyroid hormone levels at baseline and follow-up points.

Main Results:

  • Seventy-six children received stoss therapy.
  • Significant and sustained increases in 25-OHD levels observed at 1, 3, and 6 months post-therapy compared to baseline (<50 nmol/L).
  • No significant alterations in serum calcium, phosphate, or parathyroid hormone levels were noted.

Conclusions:

  • Stoss therapy is a safe and effective method for achieving and maintaining adequate 25-hydroxyvitamin D levels (>50 nmol/L) in children with IBD over six months.
  • Further prospective research is warranted to confirm these findings and explore additional benefits of stoss therapy in this population.
Abstract

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