Related Experiment Video

Updated: Apr 14, 2026

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

1.5K

Validation of the V(max) metabolic cart in a simulated pediatric model

Craig D Smallwood, Andrew Gouldstone, Nilesh M Mehta

    JPEN. Journal of Parenteral and Enteral Nutrition
    |April 18, 2015
    PubMed
    Abstract

    No abstract available in PubMed .

    More Related Videos

    Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT07:07

    Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

    Published on: May 2, 2017

    14.5K
    Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine06:09

    Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

    Published on: January 12, 2024

    1.1K

    Related Concept Videos

    Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

    Pharmacokinetics in Pediatric Patients: Drug Metabolism

    In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
    360
    One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance00:56

    One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

    Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
    In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
    494
    One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution01:09

    One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution

    The one-compartment open model is a simplified approach used in pharmacokinetics to understand the distribution and elimination of a drug administered through an intravenous bolus. This model assumes rapid drug dispersal throughout the body and elimination using a first-order process. Key pharmacokinetic parameters, such as the elimination rate constant (k), half-life (t1/2), and the apparent volume of distribution (Vd), can be estimated from this model. The elimination rate is calculated...
    1.1K
    One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model01:12

    One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model

    Extravascular administration, such as oral or intramuscular routes, is a non-invasive drug delivery method, often preferred for ease and patient compliance. A key factor here is absorption, which dictates how quickly and effectively the drug enters the bloodstream from the administration site. Absorption follows either zero-order or first-order kinetics.
    Zero-order absorption maintains a steady rate irrespective of the amount of drug left to be absorbed, making it a constant process. In the...
    529
    Model Approaches for Pharmacokinetic Data: Physiological Models01:15

    Model Approaches for Pharmacokinetic Data: Physiological Models

    Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
    356
    One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model01:15

    One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model

    The first-order absorption model for extravascular administration describes the rate at which a drug is absorbed and eliminated, following the principles of first-order kinetics. This model is vital as it provides a mathematical representation of drug behavior within the body. It also allows for the prediction and interpretation of drug absorption and elimination based on the rate of change in drug concentration over time. This model can be visualized as a plasma concentration-time profile...
    733