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Updated: Apr 14, 2026
Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
Published on: February 22, 2019
Zebrafish as a model for leukemia and other hematopoietic disorders
Parisa Rasighaemi1, Faiza Basheer2, Clifford Liongue3,4
1School of Medicine, Deakin University, Pigdons Road, Geelong, Victoria, 3217, Australia. prasigha@deakin.edu.au.
Abstract:
Zebrafish is an established model for the study of vertebrate development, and is especially amenable for investigating hematopoiesis, where there is strong conservation of key lineages, genes, and developmental processes with humans. Over recent years, zebrafish has been increasingly utilized as a model for a range of human hematopoietic diseases, including malignancies. This review provides an overview of zebrafish hematopoiesis and describes its application as a model of leukemia and other hematopoietic disorders.
