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Published on: August 11, 2015
Association of intracranial aneurysms and meningiomas: a case-control study
Young-Hoon Kim1,2, Young Jin Lee3, Jung Ho Han1,2
1Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do, Korea;
Object:
The authors aimed to assess whether the prevalence of intracranial aneurysms in patients with intracranial meningiomas was higher than that in a healthy population.
Methods:
The authors performed a hospital-based case-control study of 300 patients with newly diagnosed intracranial meningiomas and 900 age- and sex-matched controls without a history of brain tumors to evaluate any associations between intracranial aneurysms and intracranial meningiomas. Unconditional multivariate logistic regression models were used for case-control comparisons.
Results:
Intracranial aneurysms were identified in 23 patients (7.7%) and 24 controls (2.7%; p < 0.001). There was a significant association between intracranial aneurysms and intracranial meningiomas (OR 2.913, 95% CI 1.613-5.261) and hypertension (OR 1.905, 95% CI 1.053-3.446). In a subgroup analysis of the patients with newly diagnosed intracranial meningiomas, there was a significant association between intracranial aneurysms and hypertension (OR 2.876, 95% CI 1.125-7.352) and tumor volume (OR 1.012, 95% CI 1.001-1.024). These patients were also more likely than controls to have other intracranial vascular diseases (p < 0.001), such as isolated occlusion of the intracranial vessels, excluding intracranial aneurysms.
Conclusions:
The prevalence of intracranial aneurysms was higher in patients with intracranial meningiomas. Hypertension and tumor volume appear to be associated with the formation of intracranial aneurysms in these patients.
Insights
Patients with intracranial meningiomas have a higher prevalence of intracranial aneurysms compared to the general population. Hypertension and tumor volume are linked to aneurysm formation in these patients.
Area of Science:
- Neurology
- Neurosurgery
- Vascular Neurology
Background:
- Intracranial meningiomas are common primary brain tumors.
- The association between intracranial meningiomas and intracranial aneurysms requires further investigation.
Purpose of the Study:
- To determine if intracranial aneurysm prevalence is higher in patients with intracranial meningiomas compared to a healthy population.
- To identify risk factors associated with intracranial aneurysms in meningioma patients.
Main Methods:
- A hospital-based case-control study was conducted.
- 300 patients with newly diagnosed intracranial meningiomas and 900 matched controls were analyzed.
- Unconditional multivariate logistic regression models were used for statistical analysis.
Main Results:
- Intracranial aneurysms were found in 7.7% of meningioma patients versus 2.7% of controls (p < 0.001).
- A significant association was observed between intracranial aneurysms and intracranial meningiomas (OR 2.913).
- Hypertension and tumor volume were significantly associated with intracranial aneurysms in meningioma patients.
Conclusions:
- The prevalence of intracranial aneurysms is elevated in patients diagnosed with intracranial meningiomas.
- Hypertension and tumor volume are identified as potential contributing factors to aneurysm development in this patient group.
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