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Related Concept Videos

Collagens are the Major Structural Proteins of ECM01:13

Collagens are the Major Structural Proteins of ECM

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Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
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Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

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Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
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Connective Tissue Fibers and Ground Substance01:17

Connective Tissue Fibers and Ground Substance

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One of the significant functions of connective tissue is connecting tissues and organs. Unlike epithelial tissue that is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. The matrix usually includes a large amount of extracellular material produced by the connective tissue cells that are embedded within it. It plays a significant role in the functioning of this tissue. The major component of the matrix is a...
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Glycosaminoglycans01:23

Glycosaminoglycans

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Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
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Fibril-associated Collagen01:11

Fibril-associated Collagen

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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The Extracellular Matrix01:29

The Extracellular Matrix

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Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
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Wet-spinning-based Molding Process of Gelatin for Tissue Regeneration
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Collagen and gelatin.

Dasong Liu1, Mehdi Nikoo, Gökhan Boran

  • 1State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province 214122, China; email: liudasong68@163.com , zhoupeng@jiangnan.edu.cn.

Annual Review of Food Science and Technology
|April 18, 2015
PubMed
Summary
This summary is machine-generated.

Fish collagen and gelatin offer safe alternatives to mammalian sources. This review explores their structure, bioactivities, and novel applications in food, pharma, and cosmetics.

Keywords:
bioactivitybiological effectscollagengelatinnonconventional applications

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Area of Science:

  • Biochemistry
  • Materials Science
  • Food Science

Background:

  • Collagen and gelatin are widely utilized in various industries due to favorable biocompatibility and biodegradability.
  • Fish-derived collagen and gelatin are gaining prominence as alternatives to mammalian sources, addressing safety and religious concerns.
  • Understanding collagen structure variations based on source and season is crucial for optimizing extraction and applications.

Purpose of the Study:

  • To review the current understanding of collagen and gelatin structure, bioactivities, and biological effects.
  • To explore the potential of collagen-derived peptides in modulating extracellular matrix cell activities.
  • To highlight recent and novel applications of collagen, gelatin, and their hydrolysates.

Main Methods:

  • Literature review of studies investigating collagen and gelatin properties and applications.
  • Analysis of research on in vitro and in vivo models for bioactivity assessment.
  • Synthesis of information on structural variations and their impact on functional properties.

Main Results:

  • Collagen and gelatin exhibit diverse bioactivities and biological effects, particularly through hydrolysis peptides.
  • Food-derived collagen peptides can influence extracellular matrix cells post-ingestion, supporting their use in supplements and pharmaceuticals.
  • Novel applications for collagen and gelatin are continually emerging across industries.

Conclusions:

  • Fish collagen and gelatin present viable alternatives to mammalian sources with significant industrial potential.
  • Collagen-derived peptides possess bioactive properties that can be harnessed for therapeutic and nutritional applications.
  • Continued research into collagen and gelatin structure-activity relationships will drive innovation and expand their applications.