Related Experiment Video
Updated: Apr 14, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
19.1K
Biologic therapies in systemic lupus erythematosus
Christine B Bernal1, Leonid D Zamora, Sandra V Navarra
1University of Santo Tomas, Manila, Philippines.
International Journal of Rheumatic Diseases
|April 18, 2015
Summary
New therapies for systemic lupus erythematosus (SLE) show promise, particularly those targeting B-lymphocytes. Belimumab, the first approved biologic, highlights the progress in SLE treatment development.
Area of Science:
- Immunology
- Rheumatology
- Pharmacology
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant unmet needs.
- Therapeutic advancements are targeting various immune pathways involved in SLE pathogenesis.
Purpose of the Study:
- To review the progress in developing novel therapies for SLE.
- To highlight the efficacy of B-lymphocyte-targeted agents, exemplified by belimumab.
Main Methods:
- Review of clinical experience and clinical trials for SLE therapies.
- Analysis of agents targeting interferons, cytokines, T lymphocytes, and B-lymphocytes.
Main Results:
- Belimumab is the first FDA-approved biologic for SLE, demonstrating robust efficacy.
- Agents targeting B-lymphocytes show the most significant efficacy data to date.
Conclusions:
- Significant progress has been made in SLE therapy development, with B-cell targeted therapies showing particular promise.
- Challenges in clinical trial design and pharmacogenomics persist, necessitating continued drug development for SLE patients.
Related Concept Videos
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
804
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
804
01:29Inflammatory Bowel Disease IV: Pharmacological Management
989
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
989
01:28Drug Products: Biologics, Biosimilars and Interchangeables
360
Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
360
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
716
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
716
01:29Autoimmune Disorders
2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.3K
01:27Tumor Immunotherapy
2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K