Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination of Crystal Structures01:29

Determination of Crystal Structures

122
In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...
122

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Positron Range Correction with Texture Preservation Framework in PET Imaging.

ArXiv·2026
Same author

Assessing the delivery error detection sensitivity of a new 2D detector prototype for carbon ion PSQA measurements.

Journal of applied clinical medical physics·2026
Same author

Free flight angular acceptance (FFAA) variance reduction technique for SPECT Monte Carlo simulations.

Physics in medicine and biology·2026
Same author

Investigation of iterative deconvolution in <sup>177</sup>Lu-SPECT imaging for lesion dosimetry.

EJNMMI physics·2026
Same author

TGF-β1-based restoration of sodium iodide symporter expression in radioiodine-refractory differentiated thyroid cancer via engineered MSCs.

Molecular therapy : the journal of the American Society of Gene Therapy·2025
Same author

Comparison of scatter and partial volume correction techniques for quantitative SPECT imaging of <sup>225</sup>Ac.

EJNMMI physics·2025
Same journal

Effective contrast-enhanced preprocessing for intracranial artery segmentation in digital subtraction angiography.

Physics in medicine and biology·2026
Same journal

Improving Plan Quality in Adaptive Proton Therapy Using an Interactive Dose Modification Tool.

Physics in medicine and biology·2026
Same journal

Technical Note: Real-Time MLC Control and Latency Measurement Optimization with External Verification.

Physics in medicine and biology·2026
Same journal

Fetus-Specific Hematopoietic Stem Cell Dosimetry Framework for Leukemia-Relevant Target Cells During Prenatal Development.

Physics in medicine and biology·2026
Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026
Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Apr 14, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

9.0K

Simulation study of PET detector limitations using continuous crystals.

Jorge Cabello1, Ane Etxebeste, Gabriela Llosá

  • 1Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Physics in Medicine and Biology
|April 18, 2015
PubMed
Summary
This summary is machine-generated.

Continuous crystals offer better spatial resolution and depth of interaction (DoI) detection. This study used Monte Carlo simulations to optimize interaction position estimation algorithms, finding that photodetector configuration significantly impacts accuracy, especially for DoI.

More Related Videos

Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
08:43

Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System

Published on: July 21, 2015

26.5K
Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band
06:43

Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band

Published on: May 2, 2018

7.5K

Related Experiment Videos

Last Updated: Apr 14, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

9.0K
Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
08:43

Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System

Published on: July 21, 2015

26.5K
Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band
06:43

Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band

Published on: May 2, 2018

7.5K

Area of Science:

  • Medical Physics
  • Nuclear Instrumentation
  • Detector Physics

Background:

  • Continuous crystals offer superior intrinsic spatial resolution and Depth of Information (DoI) capabilities compared to pixelated crystals in radiation detectors.
  • Accurate interaction position estimation is crucial for high-performance detector systems, but algorithm performance is influenced by crystal properties and photodetector geometry.
  • Existing algorithms vary in application across different crystal dimensions and photodetector setups, necessitating a comprehensive analysis of parameter influences.

Purpose of the Study:

  • To analyze the influence of various realistic crystal and photodetector parameters on interaction position estimation accuracy, with a focus on DoI.
  • To investigate the impact of photodetector granularity, number of readout crystal faces, crystal reflectivity, and aspect ratio (AR) on estimation performance.
  • To develop and evaluate an analytical model for interaction position estimation, including a piecewise DoI error model for image reconstruction.

Main Methods:

  • Utilized Monte Carlo simulations to model interactions within continuous LYSO crystals of varying dimensions and optical properties.
  • Investigated different photodetector granulation schemes and simulated scenarios with one and two photodetectors (front and back).
  • Employed an analytical model for interaction position estimation and analyzed the impact of crystal aspect ratio and reflectivity.

Main Results:

  • Photodetector granularity primarily affects accuracy near crystal edges and corners. Intrinsic spatial resolution at the center was 0.7-0.9 mm, averaging 0.77 ± 0.18 mm across geometries.
  • Using front and back photodetectors reduced DoI bias and improved transversal resolution near corners.
  • Small AR crystals showed DoI inaccuracies at the entrance, mitigated by increasing AR, reducing reflections, or using two photodetectors. A piecewise DoI error model yielded 0.4-0.9 mm DoI resolution.

Conclusions:

  • The study provides critical insights into optimizing continuous crystal detector design for improved spatial and DoI resolution through informed photodetector and crystal parameter selection.
  • Implementing the derived DoI error model in image reconstruction significantly enhanced spatial resolution variability (0.39 mm) compared to systems without DoI correction.
  • The findings demonstrate the potential of continuous crystals and advanced estimation algorithms to advance radiation detection technologies, particularly in medical imaging applications.