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Gradient Spin Echo (GraSE) imaging for fast myocardial T2 mapping.

Alois M Sprinkart1,2, Julian A Luetkens3, Frank Träber4

  • 1Department of Radiology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany. martin.sprinkart@ukb.uni-bonn.de.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|April 18, 2015
PubMed
Summary

This study developed a fast and reliable gradient-spin-echo (GraSE) technique for quantitative myocardial T2 mapping using cardiovascular magnetic resonance (CMR). The optimized GraSE sequence accurately measures T2 relaxation times, aiding in diagnosing acute myocardial injuries.

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Area of Science:

  • Cardiovascular Magnetic Resonance (CMR) imaging.
  • Quantitative imaging techniques.
  • Myocardial tissue characterization.

Background:

  • Quantitative CMR techniques are increasingly important in research.
  • Myocardial T2 mapping shows promise for diagnosing myocardial edema in acute conditions.

Purpose of the Study:

  • To establish a gradient-spin-echo (GraSE) imaging technique for myocardial T2 mapping.
  • To evaluate the accuracy and reproducibility of the developed GraSE sequence.

Main Methods:

  • Developed a modified GraSE sequence for single-breath-hold myocardial T2 mapping at 1.5 Tesla.
  • Evaluated four GraSE variants in vitro and in 20 healthy volunteers.
  • Assessed inter-study, intra-reader, and inter-reader reproducibility.

Main Results:

  • An optimized 6-echo GraSE sequence demonstrated excellent agreement with the gold standard.
  • Healthy volunteers showed a global myocardial T2 relaxation time of 52.2 ± 2.0 ms.
  • Patients with acute myocardial injury exhibited prolonged T2 relaxation times (mean: 61.3 ± 6.7 ms).

Conclusions:

  • Optimized GraSE CMR enables robust, reliable, and fast myocardial T2 mapping for quantitative tissue characterization.
  • GraSE-based T2 mapping can potentially complement qualitative CMR in acute myocardial injury patients.