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Motor neuron transduction after intracisternal delivery of AAV9 in a cynomolgus macaque
Peter Bell1, Christian Hinderer, Jean-Pierre Louboutin
11 Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104.
Human Gene Therapy Methods
|April 18, 2015
Abstract:
The image shows a section of the lumbar spinal cord from a cynomolgus macaque that had received AAV9.CB.EGFP via the cisterna magna. Expression of GFP in multiple motor neurons is visible. Injection into the cerebrospinal fluid has been shown to be an effective route of vector administration for neuron transduction.
