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Lung function changes from childhood to adolescence: a seven-year follow-up study
Pavilio Piccioni1, Roberta Tassinari2, Aurelia Carosso3
1Unit of Respiratory Medicine, National Health Service, ASL TO2, Torino, Italy. ppiccioni@qubisoft.it.
BMC Pulmonary Medicine
|April 18, 2015
Summary
This study tracked children's lung function and asthma symptoms over seven years. Persistent asthma symptoms were linked to significant changes in lung function, particularly in the FEV1/FVC ratio and FEF25-75.
Area of Science:
- Pediatric Respiratory Medicine
- Pulmonary Function Testing
- Childhood Asthma Epidemiology
Background:
- Investigated respiratory health in children in Torino, Italy.
- Assessed lung function development from childhood to adolescence.
- Examined asthma symptom changes and their impact on lung function.
Purpose of the Study:
- To evaluate lung function development in children.
- To analyze the impact of persistent asthma symptoms on lung function.
- To compare observed lung function data with Global Lung Function Initiative (GLI) reference values.
Main Methods:
- Conducted a 7-year longitudinal study (2003-2010) with children aged 4-5 years.
- Utilized standardized SIDRIA questionnaires for health information.
- Performed spirometry measurements including FVC, FEV1, FEV1/FVC%, and FEF25-75.
Main Results:
- 242 children completed both surveys; phenotypes included asymptomatic, early transient, late onset, and persistent asthma symptoms.
- Global Lung Function Initiative (GLI) predicted values showed minor differences, except for FVC and FEF25-75.
- Asthma symptoms at follow-up correlated with decreased FEV1/FVC ratio and smaller FEF25-75 increase in persistent cases.
Conclusions:
- Global Lung Function Initiative (GLI) equations are suitable for assessing lung function development, particularly lung volumes.
- FEF25-75 measurements may serve as a valuable indicator in childhood asthma research and clinical practice.
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