Effects of magnesium sulfate on hemodynamic response to carbon dioxide pneumoperitoneum in patients undergoing...

Carbon dioxide pneumoperitoneum (PP) for laparoscopic surgery increases arterial pressure, heart rate, and systemic vascular resistance. In this randomized, double blind, prospective clinical study; we investigated the efficacy of magnesium sulfate to prevent adverse hemodynamic response associated with PP in patients undergoing laparoscopic cholecystectomy.

Sixty patients, of either sex (18-65 years of age), undergoing elective laparoscopic cholecystectomy were randomly allocated in one of the two groups containing 30 patients each. Group M received magnesium sulfate 30 mg/kg intravenously as a bolus before PP. Group C received same volume of 0.9% saline.

Mean arterial pressure and heart rate were significantly less throughout the period of pneumoperitoneum in patients of group M. Intravenous labetalol was required in 40% (12 out of 30) of the patients in group C to control intraoperative hypertension and it was clinically significant in comparison to group M.

Magnesium sulfate administered before PP attenuates adverse hemodynamic response and provides hemodynamic stability during PP created for laparoscopic surgery.