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A comparative study on monitored anesthesia care.

Jayashree Sen1, Bitan Sen2

  • 1Department of Anesthesia, Goldfield Institute of Medical Sciences and Research, Ballabgargh, Faridabad, Haryana, India.

Anesthesia, Essays and Researches
|April 18, 2015
PubMed
Summary
This summary is machine-generated.

Fortwin-phenergan-midazolam (FPM) offers superior sedation and analgesia compared to ketamine-midazolam (KM) for monitored anesthesia care. FPM demonstrated better hemodynamic stability, longer-lasting effects, and higher patient satisfaction.

Keywords:
Fortwinketaminelocal anesthesiamidazolammonitored anesthesiaphenergansedation

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Monitored anesthesia care (MAC) relies on effective sedation and analgesia.
  • Comparing drug combinations is crucial for optimizing patient outcomes and safety.

Purpose of the Study:

  • To compare the efficacy, hemodynamic effects, and duration of sedation and analgesia between fortwin-phenergan-midazolam (FPM) and ketamine-midazolam (KM) combinations.
  • To evaluate patient satisfaction and recovery time under MAC.

Main Methods:

  • A randomized study of 50 patients undergoing various surgeries under local anesthesia.
  • Patients received either FPM or KM intravenous infusions, with sedation titrated to Ramsay sedation score (RSS) of 3.
  • Hemodynamic parameters (MAP, HR), saturation, sedation duration, rescue needs, patient satisfaction, and time to Aldrete score of 10 were recorded.

Main Results:

  • The KM group showed significant increases in heart rate (HR) and mean arterial pressure (MAP) compared to the FPM group.
  • Higher target sedation levels (RSS ≥ 3) were achieved in the FPM group (92%) versus the KM group (48%).
  • The FPM group experienced longer durations until rescue sedation was needed (66.96 min vs. 32.80 min) and reported higher patient satisfaction (6.12 vs. 4.40).

Conclusions:

  • The FPM combination is superior to the KM combination for MAC.
  • FPM offers better hemodynamic stability, prolonged analgesia, and enhanced patient satisfaction.
  • These findings support FPM as a preferred regimen for specific MAC procedures.