Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structure and Function of Platelets

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of Maxillary Sinuses in Girls and Boys from Birth to Age 18 Based on Computed Tomography Investigation.

Diagnostics (Basel, Switzerland)·2026

Same author

Persistently increased frequency of diabetic ketoacidosis in new-onset type 1 diabetes in Polish children: nationwide analysis 2019-2022.

Frontiers in endocrinology·2026

Same author

Keratins and desmosomal proteins: Utility for molecular subtype identification in muscle-invasive bladder cancer.

Virchows Archiv : an international journal of pathology·2026

Same author

Practical tips for the use of automated insulin delivery systems in individuals with diabetes during minor procedures performed under sedation or anesthesia and during labor.

Polish archives of internal medicine·2026

Same author

Evolving Patterns of TPO-RA Use in Children: A Decade of Single-Centre Experience and Narrative Review.

International journal of molecular sciences·2026

Same author

Complete radiographic response to immunotherapy in a patient with metastatic anaplastic thyroid cancer - a case report and review of the literature.

Frontiers in oncology·2026

Search research articles

Related Experiment Video

Updated: Dec 23, 2025

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

Altered platelets' morphological parameters in children with type 1 diabetes – a case-control study.

Beata Malachowska¹, Bartlomiej Tomasik², Agnieszka Szadkowska³

¹Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, 36/50 Sporna St., 91-738, Lodz, Poland. beata.malachowska@stud.umed.lodz.pl.

BMC Endocrine Disorders

|April 18, 2015

Summary

Children with type 1 diabetes (T1DM) exhibit platelet morphological changes indicating hyperreactivity. Poorer metabolic control in these young patients is linked to increased platelet counts, potentially raising future cardiovascular event risk.

More Related Videos

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Published on: January 10, 2025

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Related Experiment Videos

Last Updated: Dec 23, 2025

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Published on: January 10, 2025

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Area of Science:

Pediatric Endocrinology
Hematology
Cardiovascular Research

Background:

Platelet hyperreactivity is a known risk factor for cardiovascular events in adults with type 2 diabetes.
Limited data exists on platelet alterations in children with type 1 diabetes.
This study investigates platelet morphology and function in pediatric type 1 diabetes.

Purpose of the Study:

To determine if platelet morphology or function is altered in children with type 1 diabetes.
To assess potential predisposition to future cardiovascular events.
To explore the relationship between metabolic control and platelet parameters.

Main Methods:

A cohort of 389 children with type 1 diabetes (T1DM) was studied.
An age- and sex-matched control group of 389 children was established.
Platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR), and HbA1c levels were measured.

Main Results:

Children with T1DM showed significantly higher MPV, PDW, and P-LCR compared to controls.
Platelet counts (PLT) were similar between the groups.
Higher platelet counts were associated with poorer metabolic control (HbA1c) after adjusting for confounding factors.

Conclusions:

Pediatric patients with T1DM demonstrate morphological evidence of platelet hyperreactivity.
Increased platelet counts in T1DM are linked to poorer metabolic control.
These platelet alterations may predispose children with T1DM to future cardiovascular events.