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Published on: October 27, 2014
Peritumoral edema shown by MRI predicts poor clinical outcome in glioblastoma
Chen-Xing Wu1, Guo-Shi Lin2, Zhi-Xiong Lin3,4
1Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, China. albert978@126.com.
Background:
Magnetic resonance imaging (MRI) plays an irreplaceable role in the preoperative diagnosis of glioma, and its imaging features are the base of making treatment decisions in patients with glioma, but it is still controversial whether peritumoral edema shown by MRI from preoperative routine scans are associated with patient survival. The aim of this study was to assess the prognostic value of preoperative MRI features in patients with glioblastoma.
Methods:
A retrospective review of 87 patients with newly diagnosed supratentorial glioblastoma was performed using medical records and MRI data from routine scans. The Kaplan-Meier method and COX proportional hazard model were applied to evaluate the prognostic impact on overall survival of pretreatment MRI features (including peritumoral edema, edema shape, necrosis, cyst, enhancement, tumor crosses midline, edema crosses midline, and tumor size).
Results:
In addition to patient age, Karnofsky performance status (KPS) and postoperative chemoradiotherapy, peritumoral edema extent and necrosis on preoperative MRI were independent prognostic indicator for poor survival. Furthermore, patients with two unfavorable conditions (major edema and necrosis) had a shorter overall survival compared with the remainder.
Conclusions:
Our data confirm that peritumoral edema extent and necrosis are helpful for predicting poor clinical outcome in glioblastoma. These features were easy to determine from routine MRI scans postoperatively and therefore could provide a certain instructive significance for clinical activities.
Insights
Peritumoral edema extent and necrosis on preoperative MRI are independent indicators of poor survival in glioblastoma patients. These findings aid in predicting clinical outcomes and guiding treatment decisions.
Area of Science:
- Neuro-oncology
- Radiology
- Medical imaging
Background:
- Magnetic resonance imaging (MRI) is crucial for glioma diagnosis and treatment planning.
- The prognostic value of preoperative MRI features, specifically peritumoral edema, for glioblastoma survival remains debated.
Purpose of the Study:
- To evaluate the prognostic significance of preoperative MRI features in patients diagnosed with glioblastoma.
Main Methods:
- Retrospective analysis of 87 newly diagnosed supratentorial glioblastoma patients.
- Utilized routine MRI data and medical records.
- Applied Kaplan-Meier and COX proportional hazard models to assess prognostic impact on overall survival.
Main Results:
- Peritumoral edema extent and necrosis on preoperative MRI independently predicted poor survival.
- Patients with both major edema and necrosis had significantly shorter overall survival.
- Age, Karnofsky performance status (KPS), and postoperative chemoradiotherapy also influenced survival.
Conclusions:
- Preoperative MRI features, including peritumoral edema extent and necrosis, are valuable for predicting poor clinical outcomes in glioblastoma.
- These easily determinable features from routine MRI scans offer significant clinical guidance.
