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Genetic variants in AKR1B10 associate with human eating behavior
Kerstin Rohde1, Martin Federbusch2, Annette Horstmann3,4
1IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany. Kerstin.Rohde@medizin.uni-leipzig.de.
BMC Genetics
|April 19, 2015
Summary
Genetic variants in the Aldoketoreductase 1B10 (AKR1B10) gene may influence human eating behavior. This study explored AKR1B10 gene variants and their association with eating patterns and related traits.
Area of Science:
- Genetics
- Behavioral Science
- Human Physiology
Background:
- The Aldoketoreductase 1B10 (AKR1B10) gene encodes an enzyme potentially involved in nutrient detoxification.
- Reduced AKR1B10 mRNA expression is observed in brain regions regulating eating behavior in rats.
- This suggests a possible role for AKR1B10 in human eating behavior regulation.
Purpose of the Study:
- To investigate the association between genetic variants of the AKR1B10 gene and human eating behavior.
- To explore potential links between AKR1B10 variants and anthropometric/behavioral traits.
Main Methods:
- Genotyping of 5 AKR1B10 genetic variants in two independent German cohorts (Sorbs population and another cohort).
- Statistical analysis to assess associations between variants and eating behavior traits (disinhibition, restraint).
- Examination of relationships with waist circumference, smoking, and coffee consumption.
Main Results:
- Nominal associations were found between AKR1B10 variants (rs10232478, rs1834150, rs782881) and eating disinhibition in the Sorbs cohort.
- Significant associations were observed for variants rs1834150 and rs782881 with waist, smoking, and coffee consumption.
- Replication analyses supported the association of rs1834150 with eating disinhibition and restraint, with combined P-values indicating significance.
Conclusions:
- Genetic variants within the AKR1B10 gene locus show potential influence on human eating behavior.
- The findings warrant further investigation into the role of AKR1B10 in the complex regulation of appetite and food intake.
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