Related Experiment Video

Updated: Apr 14, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.5K

Host response to respiratory syncytial virus infection

Lourdes Arruvito1, Silvina Raiden, Jorge Geffner

  • 1aInstituto de Inmunología, Genética y Metabolismo (INIGEM), UBA-CONICET, Hospital de Clínicas 'José de San Martín' bHospital General de Niños 'Pedro de Elizalde' cInstituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), UBA-CONICET, Buenos Aires, Argentina.

Current Opinion in Infectious Diseases
|April 19, 2015
PubMed

Insights

Respiratory syncytial virus (RSV) infection poses a significant threat to infants, causing severe illness and death. Understanding the immune response is crucial for developing effective vaccines and treatments against this common respiratory virus.

Area of Science:

  • Immunology
  • Virology
  • Pediatrics

Background:

  • Respiratory syncytial virus (RSV) is a major cause of infant bronchiolitis and hospitalization, with no current vaccine.
  • Therapeutic options for RSV are limited, primarily supportive care.
  • Significant knowledge gaps exist regarding immune mechanisms and risk factors for severe RSV infection.

Purpose of the Study:

  • To review recent findings on the immune response to RSV infection.
  • To understand the role of innate and adaptive immunity in RSV pathogenesis and resolution.
  • To highlight the importance of studying immune responses in young children, the primary risk group.

Main Methods:

  • Review of recent studies on RSV immunology.
  • Analysis of findings from mouse models and human infant studies.
  • Examination of the roles of various immune cells (T cells, innate immune cells) in RSV infection.

Main Results:

  • The early innate immune response is critical in RSV bronchiolitis pathogenesis.
  • Adaptive immune responses involving TH1, TH2, TH17, regulatory T cells, and CD8 T cells are key to RSV infection.
  • Recent research has advanced understanding of immune responses in high-risk young children.

Conclusions:

  • A complete understanding of protective and harmful immune responses to RSV in young children is still needed.
  • Further research is required to address remaining challenges in RSV immunology.
  • Developing effective interventions for RSV necessitates a deeper comprehension of the immune system's role.
Abstract

More Related Videos

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay09:14

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

11.7K
Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

17.6K

Related Concept Videos

Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
1.9K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
5.2K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.6K
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
1.6K
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
681
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
41