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Clinical chronopharmacology of oral nitrates
B Lemmer1, B Scheidel, G Stenzhorn
1Zentrum der Pharmakologie, J. W. Goethe-Universität Frankfurt.
Zeitschrift Fur Kardiologie
|January 1, 1989
Abstract:
The clinical-chronopharmacological investigations with oral nitrates (ISDN, IS-5-MN) demonstrate that the drugs' pharmacokinetics and/or hemodynamic effects are circadian phase-dependent. For both an immediate-release and a sustained-release preparation of IS-5-MN peak drug concentrations coincided with peak drug effects after morning but not after evening drug application. Results indicate a circadian phase-dependency in the dose-response relationship of oral nitrates.