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Related Experiment Video

Updated: Apr 14, 2026

Microfluidics in Assessing Platelet Function
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Intraoperative changes in platelet function in relation to moderate haemorrhage.

Jonathan J Hetherington1, Isobel Ford2, G Patrick Ashcroft2

  • 1Aberdeen Royal Infirmary, NHS Grampian.

Thrombosis Research
|April 19, 2015
PubMed
Summary

Platelet function changes during hip replacement surgery, showing altered responsiveness to common agonists like ADP. These findings highlight the dynamic nature of platelet activity in response to surgical blood loss.

Keywords:
HaemorrhagePlatelet aggregationPlatelet function testsSurgery

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Area of Science:

  • Surgical Research
  • Hematology
  • Platelet Physiology

Background:

  • Hemorrhage is linked to impaired hemostasis, with a known focus on coagulation factors.
  • Platelet function is critical in hemostasis, yet its dynamic changes during surgery are poorly understood.

Purpose of the Study:

  • To assess short-term, intra-operative alterations in platelet function using whole blood impedance aggregometry.
  • To evaluate platelet aggregation in response to adenosine diphosphate (ADP) and other agonists during hip arthroplasty.
  • To determine the feasibility of performing platelet aggregometry in the operating theatre.

Main Methods:

  • Six peri-operative arterial blood samples were analyzed from patients undergoing primary cemented hip arthroplasty.
  • Whole blood impedance aggregometry was performed using the Multiplate Impedance Aggregometer.
  • Platelet responses to four agonists (ADP, TRAP, Collagen, Arachidonic Acid) were evaluated.

Main Results:

  • A statistically significant change in platelet response to ADP was observed throughout the surgery.
  • Platelet responsiveness initially decreased and then increased in the later stages of the operation.
  • Similar patterns of change were noted for other agonists (TRAP, Collagen, Arachidonic Acid).

Conclusions:

  • Platelet function, measured by impedance aggregometry, is altered by the surgical stimulus of blood loss during hip arthroplasty.
  • The clinical implications of these dynamic changes in platelet function require further investigation.
  • The potential for therapeutic manipulation of these surgical-induced platelet changes remains to be determined.