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Pediatric thrombotic events: a single-center study

Annika van den Broek1, Vaughan K Williams, Tamas Revesz

  • 1*Franciscus Ziekenhuis, Roosendaal, The Netherlands †Women's and Children's Hospital, North Adelaide, Australia.

Journal of Pediatric Hematology/Oncology
|April 19, 2015
PubMed

Insights

This study found no conclusive evidence of increased pediatric venous thromboembolism (TE) incidence. However, thrombophilic risk factors were present in most children diagnosed with TE.

Area of Science:

  • Pediatric Medicine
  • Hematology
  • Vascular Medicine

Background:

  • Recent literature suggests a rise in pediatric venous thromboembolism (TE).
  • Understanding the incidence and risk factors for TE in children is crucial.

Purpose of the Study:

  • To investigate the incidence of pediatric TE between 2000 and 2012.
  • To identify factors contributing to TE development in children.
  • To analyze the recurrence rate of TE in pediatric patients.

Main Methods:

  • Retrospective data collection from pediatric patients (0-18 years) with thrombotic events.
  • Study period: January 2000 to May 2012.
  • Analysis of patient demographics, TE location, and presence of thrombophilic risk factors.

Main Results:

  • No conclusive evidence of increased pediatric TE incidence was found during the study period.
  • The peripheral venous system was the most common site for TE, followed by cerebral vascular accidents.
  • A thrombophilic risk factor was identified in 84% of the pediatric patients.
  • Recurrence of TE (a second event) occurred in 4.5% of the children.

Conclusions:

  • The study did not support an increasing trend in pediatric TE incidence in the studied population.
  • Thrombophilic risk factors are highly prevalent in children experiencing TE.
  • Peripheral venous TE is more common than cerebral vascular accidents in this pediatric cohort.

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