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Th17 cytokine deficiency in patients with Aspergillus skull base osteomyelitis

Corine E Delsing1, Katharina L Becker2, Anna Simon3

  • 1Department of Internal Medicine and Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands. C.Delsing@mst.nl.

BMC Infectious Diseases
|April 19, 2015
PubMed
Abstract

Insights

Patients with fungal skull base osteomyelitis (SBO) show impaired Th17 immune responses. Improving IL-17 and IL-22 production may aid in treating Aspergillus SBO.

Area of Science:

  • Immunology
  • Mycology
  • Infectious Diseases

Background:

  • Fungal skull base osteomyelitis (SBO) is a severe infection, primarily caused by Aspergillus species.
  • It often arises from otitis externa or sinonasal infections.
  • Understanding immune defects is crucial for explaining susceptibility to Aspergillus SBO.

Purpose of the Study:

  • To investigate innate and adaptive immune responses in patients with Aspergillus SBO.
  • To identify specific immune system defects contributing to susceptibility.
  • To explore potential therapeutic strategies targeting immune responses.

Main Methods:

  • Peripheral blood mononuclear cells (PBMCs) from Aspergillus SBO patients and healthy volunteers were analyzed.
  • PBMCs were stimulated with microbial antigens, including Candida albicans and Aspergillus fumigatus.
  • Proinflammatory (IL-6, TNFα, IL-1β) and T-helper (IFNγ, IL-17, IL-22) cytokines were quantified using ELISA.

Main Results:

  • No significant differences in proinflammatory cytokine responses were observed between SBO patients and controls.
  • A significant decrease in Th17 responses (IL-17 and IL-22 production) to Candida and Aspergillus was found in SBO patients.
  • Th1 cytokine (IFNγ) responses did not differ between the groups.

Conclusions:

  • Patients with Aspergillus SBO exhibit specific defects in Th17-mediated immune responses.
  • Reduced IL-17 and IL-22 levels impair antifungal host defense.
  • Adjuvant immunotherapy aimed at enhancing IL-17 and IL-22 production may benefit Aspergillus SBO patients.

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