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[Clinical characteristics of the convulsion syndrome in newborn infants]
Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
|January 1, 1989
Insights
This study investigated 272 newborns with neurological issues and seizures, finding structural brain changes in over half and metabolic disorders in 13.8%. Recommendations were made for tailored convulsive syndrome therapy.
Area of Science:
- Neonatal neurology
- Pediatric neurophysiology
- Clinical biochemistry
Context:
- Perinatal neurological pathology and convulsive syndrome are significant concerns in newborns.
- Early diagnosis and understanding of underlying causes are crucial for effective management.
Purpose:
- To investigate the prevalence of cerebral structural changes and metabolic disorders in newborns presenting with convulsive syndrome.
- To establish evidence-based recommendations for the therapy of neonatal convulsive syndrome.
Summary:
- A study of 272 newborns with perinatal neurological pathology and convulsive syndrome utilized EEG, USI, diaphanoscopy, CT, and blood tests (glucose, Calcium, Magnesium, bilirubin, pyridoxal-5-phosphate).
- Cerebral structural changes were identified in 50.8% of patients.
- Metabolic disorders were detected in 13.8% of the studied newborns.
Impact:
- Highlights the high incidence of structural brain abnormalities in newborns with seizures.
- Underscores the importance of screening for metabolic derangements in neonatal convulsive syndrome.
- Provides a basis for individualized therapeutic strategies for neonatal seizures.
Abstract:
A total of 272 mature newborn babies with perinatal neurological pathology and convulsive syndrome were studied. EEG, USI, diaphanoscopy, CT, blood tests for glucose, Calcium, Magnesium, bilirubin, pyridoxal-5-phosphate were performed. Cerebral structure was changed in 50.8 of the patients, and metabolic disorders detected in 13.8%. The recommendations were offered for the therapy of convulsive syndrome in newborns with due account of the above stated disorders.