Related Experiment Video
Updated: Apr 14, 2026

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision
Published on: May 2, 2025
Long-term outcomes of a benign biliary stricture protocol
Daniel M DePietro1, Richard D Shlansky-Goldberg1, Michael C Soulen1
1Department of Radiology, Division of Interventional Radiology, Perelman School of Medicine of the University of Pennsylvania, 1 Silverstein, 3400 Spruce St., Philadelphia, PA 19104.
This study shows that a structured protocol for percutaneous treatment of benign biliary strictures provides durable long-term success. Percutaneous intervention is an effective therapy for these challenging biliary strictures.
Area of Science:
- Interventional Radiology
- Gastroenterology
- Hepatology
Background:
- Benign biliary strictures can cause significant morbidity.
- Percutaneous treatment offers a minimally invasive approach to manage these strictures.
Purpose of the Study:
- To evaluate the long-term outcomes of a structured protocol for percutaneous treatment of benign biliary strictures.
- To assess the durability and efficacy of this interventional approach.
Main Methods:
- A protocol involving staged catheter upsizing, balloon dilation, and prolonged stenting was used.
- Seventy-one patients with benign biliary strictures were enrolled.
- Kaplan-Meier analysis was performed to determine long-term patency rates.
Main Results:
- Stricture patency was achieved in 65% of patients entering the protocol and 87% of those completing it.
- Long-term Kaplan-Meier analysis showed stricture patency probabilities of 84% at 1 year, decreasing to 67% at 10 years.
- Anastomotic strictures were the most common type (64%).
Conclusions:
- A structured percutaneous treatment protocol yields durable long-term results for benign biliary strictures.
- Percutaneous treatment is an effective therapeutic option for managing benign biliary strictures.
- The protocol demonstrates sustained efficacy over a decade of follow-up.
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