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Related Experiment Videos

Is oxytocin present in platelets?

F M Helmerhorst1, A M van den Boogaard, N Naaktgeboren

  • 1Department of Gynecology and Reproductive Medicine, University Hospital, Leiden, The Netherlands.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|September 1, 1989
PubMed
Summary
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Oxytocin (OT) is not found to be bound to platelets in blood plasma. This study investigated platelet-rich plasma from women undergoing in-vitro fertilization, finding no evidence of platelet-bound oxytocin.

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Pharmacology

Background:

  • Arginine-vasopressin (AVP) is largely bound to platelet membranes in peripheral blood.
  • Oxytocin (OT) shares structural similarities with AVP, suggesting potential similar binding characteristics.

Purpose of the Study:

  • To investigate if oxytocin (OT) is bound to platelets in human plasma.
  • To examine OT levels in platelet-rich versus platelet-poor plasma samples.

Main Methods:

  • Plasma samples were collected from patients undergoing ovarian super-stimulation for in-vitro fertilization.
  • Samples were treated with acid, repeated freezing/thawing, and sonification to release potential bound OT.
  • Oxytocin concentrations were measured in both platelet-rich and platelet-poor plasma fractions.

Related Experiment Videos

Main Results:

  • No significant difference in oxytocin concentrations was observed between platelet-rich and platelet-poor plasma samples.
  • The applied methods did not reveal any evidence of OT being confined to or bound by platelets.

Conclusions:

  • Plasma oxytocin is not significantly bound or confined to platelets.
  • The findings suggest that oxytocin circulates freely in the plasma, unlike arginine-vasopressin.