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Inflammation and Arterial Hypertension: From Pathophysiological Links to Risk Prediction

Panagiota Pietri, Charalambos Vlachopoulos1, Dimitris Tousoulis

  • 1Hypertension Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Profiti Elia 24, 14575 Athens, Greece. cvlachop@otenet.gr.

Current Medicinal Chemistry
|April 21, 2015
PubMed

Insights

Low-grade inflammation plays a key role in atherosclerosis and cardiovascular disease. This review discusses the bidirectional link between arterial hypertension and inflammation, highlighting clinical implications.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Pathophysiology

Background:

  • Low-grade inflammation is central to atherosclerosis and cardiovascular disease (CVD).
  • Inflammatory activation increases cardiovascular events, acting as a substrate or trigger.
  • Arterial hypertension and inflammation share a bidirectional relationship, each exacerbating the other.

Purpose of the Study:

  • To review the association between arterial hypertension and low-grade inflammation.
  • To discuss the underlying pathophysiological pathways.
  • To explore the clinical implications of this relationship.

Main Methods:

  • Literature review of studies investigating the link between hypertension and inflammation.
  • Analysis of data on inflammatory biomarkers in hypertensive patients.
  • Discussion of proposed mechanisms connecting hypertension and inflammation.

Main Results:

  • Inflammatory biomarkers like high-sensitivity C-reactive protein predict hypertension incidence and outcomes.
  • Arterial hypertension can enhance inflammatory processes.
  • Inflammation can contribute to the development and progression of hypertension.

Conclusions:

  • The interplay between arterial hypertension and low-grade inflammation is significant in cardiovascular health.
  • Understanding these pathways is crucial for managing hypertensive patients and preventing cardiovascular events.
  • Targeting inflammation may offer novel therapeutic strategies for hypertension and related CVD.

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