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Provent therapy for obstructive sleep apnea: Impact of nasal obstruction

Michael Friedman1,2, Michelle S Hwang2, Sreeya Yalamanchali2

  • 1Section of Sleep Surgery (m.f.), Rush University Medical Center, Chicago, Illinois, U.S.A.

The Laryngoscope
|April 21, 2015
PubMed
Abstract

Insights

Provent therapy for obstructive sleep apnea (OSA) showed higher failure rates in patients with nasal obstruction. Non-obstructed patients experienced greater benefits, suggesting nasal obstruction correction may improve Provent efficacy.

Area of Science:

  • Sleep Medicine
  • Respiratory Medicine
  • Medical Devices

Background:

  • Obstructive sleep apnea (OSA) is a common sleep disorder characterized by repeated airway collapse during sleep.
  • Continuous positive airway pressure (CPAP) is a standard treatment, but adherence can be challenging.
  • Alternative therapies like Provent, a nasal expiratory positive airway pressure device, are used for OSA management.

Purpose of the Study:

  • To evaluate the impact of nasal obstruction on the effectiveness, success, and adherence of Provent therapy in patients with OSA.
  • To compare Provent therapy outcomes between patients with and without significant nasal obstruction.

Main Methods:

  • A prospective, two-arm clinical pilot study was conducted at a single site.
  • Patients with OSA who failed CPAP were enrolled and divided into two groups based on the severity of nasal obstruction.
  • Sleep studies were performed before and after 10 days of Provent use to assess efficacy.

Main Results:

  • Overall, the apnea-hypopnea index (AHI) significantly decreased in the total patient population.
  • Patients without significant nasal obstruction (arm 1) showed statistically significant improvements in AHI, oxygen desaturation index (ODI), and minimum oxygen saturation.
  • Patients with moderate nasal obstruction (arm 2) showed non-significant improvements in AHI and ODI.

Conclusions:

  • Provent therapy demonstrated a high failure rate in this OSA patient cohort.
  • Patients without nasal obstruction experienced significantly better outcomes with Provent compared to those with obstruction.
  • Addressing nasal obstruction prior to or during Provent therapy may be crucial for successful treatment of OSA.
Keywords:
Obstructive sleep apneaProvent sleep apnea therapy

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