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Updated: Apr 14, 2026

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

The Center for Integrated Molecular Brain Imaging (Cimbi) database.

Gitte M Knudsen¹, Peter S Jensen², David Erritzoe²

¹Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark; Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.

|April 21, 2015

Summary

This summary is machine-generated.

The Cimbi database offers extensive neuroimaging and biological data for brain research, particularly for the serotonergic system. This resource supports diverse studies in healthy individuals and patients with various conditions.

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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

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Published on: September 20, 2015

Area of Science:

Neuroscience
Neuroimaging
Psychiatry

Background:

The Lundbeck Foundation Center for Integrated Molecular Brain Imaging (Cimbi) established a structured database and biobank in 2008.
Data acquired comply with Danish Data Protection Agency regulations, ensuring quality and standardization.

Purpose of the Study:

To describe the Cimbi multimodality neuroimaging database and biobank.
To provide a high-quality, structured resource for hypothesis-generating and hypothesis-driven research.

Main Methods:

The database includes PET and MRI scans (1100 PET, 1000 MRI) from healthy volunteers and patients.
Additional data include genetic, biochemical, questionnaire, and neuropsychological test results.
The biobank contains blood and saliva samples from approximately 500 healthy volunteers and 300 patients.

Main Results:

The dataset is particularly relevant for research on the serotonergic system, including receptors (5-HT1A, 5-HT1B, 5-HT2A, 5-HT4) and the 5-HT transporter (5-HTT).
The database supports studies on conditions such as major depression, dementia, substance abuse, obesity, and impulsive aggression.
Data are continuously being added to the Cimbi database and biobank.

Conclusions:

The Cimbi database and biobank represent a valuable, comprehensive resource for neurobiological and psychiatric research.
The integrated data facilitate diverse research questions, especially concerning the serotonergic system and associated disorders.