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Published on: September 24, 2020
De novo malignancy after pancreas transplantation in Japan
Y Tomimaru1, T Ito2, S Marubashi3
1Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
Background:
Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan.
Methods:
Post-transplant patients with de novo malignancy were surveyed and characterized in Japan.
Results:
Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case.
Conclusions:
We clarified the incidence of de novo malignancy after pancreas transplantation in Japan.
