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A spreadsheet-based method for simultaneously estimating the disposition of multiple ingredients applied to skin
Matthew A Miller1, Gerald B Kasting1
1James L. Winkle College of Pharmacy, University of Cincinnati Academic Health Center, Cincinnati, Ohio.
Journal of Pharmaceutical Sciences
|April 21, 2015
Summary
A new computer model tracks skin absorption and evaporation of multiple ingredients in formulations. This multicomponent vehicle (MCV) model improves predictions compared to simpler methods, aiding drug delivery research.
Area of Science:
- Dermatology
- Pharmaceutics
- Computational modeling
Background:
- Simultaneous absorption and evaporation of multicomponent formulations on skin is complex.
- Ingredient interactions within a formulation affect their disposition.
- Accurate modeling is crucial for predicting skin penetration and efficacy.
Purpose of the Study:
- To develop a spreadsheet-based computer program for tracking multicomponent skin formulations.
- To model simultaneous absorption and evaporation processes.
- To compare model predictions with experimental skin permeation data.
Main Methods:
- Developed a multicomponent vehicle (MCV) model in a spreadsheet program.
- Incorporated thermodynamic activity models (modified ideal solution or UNIQUAC).
- Compared MCV model predictions with in vitro human skin permeation data.
Main Results:
- The MCV model successfully tracks the changing mass and thickness of skin formulations.
- Model predictions showed improved accuracy for vanillylnonamide absorption compared to simpler models.
- Thermodynamic activities within the vehicle significantly influence component disposition.
Conclusions:
- The developed MCV model provides a more accurate prediction of ingredient disposition from multicomponent skin formulations.
- This tool can enhance the design and development of topical and transdermal products.
- The model's ability to account for component interactions is key to its improved predictive power.
