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Hormone replacement therapy and longevity.

F Comhaire1

  • 1Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.

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PubMed
Summary
This summary is machine-generated.

Hormone replacement therapy, including testosterone and estrogen, significantly boosts longevity. Testosterone therapy for men with late onset hypogonadism increased survival by 9-10% over 5 years.

Keywords:
Ageinghormoneslongevityoestrogen therapytestosterone therapy

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Area of Science:

  • Endocrinology
  • Gerontology
  • Public Health

Background:

  • Hormone replacement therapy (HRT) is used for various conditions.
  • The impact of HRT on longevity requires further investigation.
  • Late onset hypogonadism (LOH) affects men, while post-menopausal women experience estrogen decline.

Purpose of the Study:

  • To evaluate the influence of hormone replacement therapy on longevity.
  • To quantify the survival benefits of testosterone and estrogen replacement.

Main Methods:

  • Analysis of published life tables.
  • Calculation of relative benefit of HRT on longevity.
  • Comparison of survival rates in HRT recipients versus control groups.

Main Results:

  • Testosterone replacement therapy (TRT) in men with LOH increased 5-year survival by 9-10%.
  • This survival increase with TRT was comparable to eugonadal men.
  • Estrogen replacement therapy (ERT) in post-menopausal women increased 5-year survival by 2.6%.

Conclusions:

  • Hormone replacement therapy demonstrably increases longevity.
  • TRT offers significant survival benefits for men with LOH.
  • ERT also contributes to increased survival rates in women.