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Updated: Apr 14, 2026
An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis
Published on: October 4, 2018
Inhibition of infectious bursal disease virus transmission using bioceramic derived from chicken feces
Chanathip Thammakarn1, Yuki Ishida2, Atsushi Suguro2
1Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo 183-8509, Japan; The United Graduate School of Veterinary Science, Gifu University, Gifu, Japan.
Abstract:
Bioceramic powder (BCX), at pH 13.0, derived from chicken feces, was evaluated for its efficacy to inactivate virus and inhibit virus horizontal transmission by fecal-oral route, using infectious bursal disease virus (IBDV) vaccine strain D78 as a challenge virus. Three 1-week-old SPF chicks were vaccinated per os and used as seeder birds. Six hours later, 3 sentinel 1-week-old SPF chicks were introduced into the same cage. Results revealed that BCX had excellent efficacy to inactivate IBDV within 3 min. Treating IBDV contaminated litter in the cage with BCX could prevent transmission of IBDV to new sensitive chicks completely. Further, transmission of IBDV to the sentinel chicks was significantly inhibited by adding BCX to litter and chicken feed. These data suggest that BCX at pH 13, derived from chicken feces, has excellent efficacy to inactivate IBDV, which can be applied in bedding materials for preventing viral transmission during production round. It is a good material that can effectively be used for enhancing biosecurity system in poultry farms.
