Macular thickness measurements using Copernicus Spectral Domain Optical Coherence Tomography

Area of Science:

• Ophthalmology
• Medical Imaging
• Retinal Imaging

Background:

• Accurate macular thickness measurements are crucial for diagnosing and monitoring various retinal diseases.
• Spectral Domain Optical Coherence Tomography (SDOCT) is a key technology for in vivo retinal imaging.

Purpose of the Study:

• To establish normative macular thickness values in the Indian population using the Copernicus SDOCT device.
• To compare measurements obtained from different OCT instruments.

Main Methods:

• Prospective study of 58 healthy subjects.
• Comprehensive ophthalmic examination and Copernicus SDOCT imaging.
• Measurement of central foveal thickness (CFT) and photoreceptor layer (PRL) thickness.

Main Results:

• Mean CFT was 173.8 ± 18.16 microns; mean PRL thickness was 65.48 ± 4.23 microns.
• No significant difference between automated and manual CFT measurements.
• CFT was significantly lower in women than in men (p=0.008).
• Retinal thickness measurements differed significantly from those obtained using Stratus and Spectralis OCT.

Conclusions:

• Normal central macular thickness in Indians using Copernicus SDOCT ranges from 138 to 242 microns.
• Different OCT instruments yield variable measurements and should not be used interchangeably.
• Instrument-specific segmentation algorithms impact macular thickness readings.