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Shift work and endocrine disorders.

M A Ulhôa1, E C Marqueze2, L G A Burgos3

  • 1Department of Medicine, UNEC, Nossa Senhora das Graças, Unity II, 35300-345 Caratinga, MG, Brazil ; IMES, Rua João Patrício Araújo, No. 179 Veneza I, Ipatinga, MG, Brazil.

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Summary
This summary is machine-generated.

Shift work disrupts metabolic processes by altering sleep-wake and feeding schedules, potentially increasing diabetes risk. This review examines these impacts on hormonal balance and overall metabolic health.

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Area of Science:

  • Chronobiology
  • Metabolic Health
  • Occupational Health

Background:

  • Shift and night work are prevalent globally, affecting millions of workers.
  • Disruptions to circadian rhythms are increasingly linked to adverse health outcomes.
  • Metabolic disorders represent a significant public health challenge.

Purpose of the Study:

  • To review the impact of shift and night work on metabolic processes.
  • To explore the role of sleep-wake cycle and feeding time alterations in metabolic disorders.
  • To synthesize current evidence on physiological changes in shift workers.

Main Methods:

  • Systematic literature review of studies published in the last 10 years.
  • Searched three electronic databases for relevant research.
  • Assessed methodological quality and applied best-evidence synthesis.

Main Results:

  • Shift work alters concentrations of key hormones: melatonin, cortisol, ghrelin, and leptin.
  • Reduced melatonin levels are associated with insulin resistance and increased diabetes risk.
  • Shift work contributes to poor sleep, sedentarism, unhealthy eating, and stress, further impacting metabolism.

Conclusions:

  • Shift work induces physiological changes that disrupt metabolic processes.
  • Alterations in circadian rhythms and hormonal balance are critical factors in shift work-related metabolic disorders.
  • Further research is needed to fully elucidate the complexity of metabolic disruptions in shift workers.