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Related Experiment Videos

Response bias in the Honolulu Heart Program.

R Benfante1, D Reed, C MacLean

  • 1Honolulu Heart Program, Kuakini Medical Center, HI 96817.

American Journal of Epidemiology
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

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This study on the Honolulu Heart Program found that while non-examined men had higher mortality and coronary heart disease rates initially, these differences diminished over time. The healthy participant effect faded, showing minimal impact on overall cardiovascular disease findings.

Area of Science:

  • Epidemiology
  • Cardiovascular Disease Research
  • Biostatistics

Background:

  • Participant selection bias can influence epidemiological study outcomes.
  • The Honolulu Heart Program investigated cardiovascular disease incidence and mortality in men.
  • Understanding response bias is crucial for interpreting long-term health study results.

Purpose of the Study:

  • To compare incidence rates of coronary heart disease, stroke, and mortality between examined and non-examined men in the Honolulu Heart Program.
  • To assess the impact and temporal trends of response bias on study findings.
  • To evaluate the 'healthy participant effect' in long-term prospective studies.

Main Methods:

  • Comparison of 14-year incidence rates (1969-1982) for major health outcomes.

Related Experiment Videos

  • Utilized identical surveillance procedures for both examined (n=8,006) and non-examined (n=3,130) cohorts.
  • Analyzed demographic and lifestyle differences between examined and non-examined groups.

    • Main Results:

    • Non-examined men exhibited higher total mortality, cancer mortality, and coronary heart disease incidence rates.
    • No significant differences in stroke incidence rates were observed between the groups.
    • Response bias effects diminished over the follow-up period, with rates converging by 10 years.

    Conclusions:

    • A small response bias was present but did not alter the relative incidence findings for cardiovascular disease.
    • The 'healthy participant advantage' diminished over time, suggesting a transient effect.
    • Monitoring non-participants is recommended in prospective studies to ensure result validity.