Related Experiment Video For Cytokine-producing capability
Updated: Apr 14, 2026
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma
Kosuke Naganawa1, Eiji Takayama2, Makoto Adachi3
1Department of Oral Biochemistry, School of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan ; Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan.
Abstract:
In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.
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